特异性CD4表面蛋白

基于George Elias2019年发表的review整理，总结了确定特异性CD4的方法和表面蛋白。

surface protein identify specific CD4

• words
  • interrogation
    • 讯问
    • 诘难
    • 质问
  • surrogate
    • adj.
    • surrogate mother
  • irrespective of age
    • regardless of age
  • subject
    • adj
    • be subject to
      • peptide-MHC class II multimers are still subject to several limitations
    • subject peoples
  • necessitate
    • verb
    • make sth necessary
• assay for identification
  • direct
    • multimers
      • 目标肽的了解和可获得性
      • HLA II分子的多样性和结合肽能力的多样性
  • indirect
    • cytokines
      • ICS
        • 死细胞
      • 亲和力矩阵
        • laborious
    • proliferation
    • surface protein
      • 早期活化marker
        • CD25
          • 在Treg上表达
        • CD69
          • TCR-independent
      • 晚期活化marker
        • HLA-DR
        • CD38
      • 特异性marker
      • 未被充分研究的marker
        • LAP
        • CD121a/CD121b
        • Treg
        • CD200
          • 循环Tfh
• surface proteins for specific CD4
  • CD40L（CD154）
    • transient
  • OX40(CD134)
  • PD-L1（CD274）
  • 4-1BB(CD137)
    • both CD4 and CD8
    • 6h stimulation
      • 41BB+CD40L- as Treg
      • 41BB-CD40L+ as Teff
    • 18-24h stimulation
      • both Treg and Teff upregulate 41BB
• George Elias, 2019, review