DNA Repair

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DNA Repair

• Error- free
  • photoreactivation
    • pyrimidine dimer
    • visible light
    • Photolyase
  • Nucleotide Excision Repair
    • a wide variety of lesions
    • endonuclease
    • DNA polymerase
    • ligase
  • Base excision repair
    • small,non-helix distorting base lesions
    • glycosylase
      • AP site
    • AP endonuclease
  • mismatch repair
    • mismatched base pairs
    • mut H, L, S and ATP
      • recognition(absence of methyl groups on GATC)
      • introduce a nick
    • Exonuclease I, MutL, MutS, DNA helicase, and ATP
      • Remove
    • DNA polymerase III holoenzyme
    • SSBP
    • Ligase
  • Homologous recombination repair
    • Lesions in replication
    • Replication
    • Strand exchange
    • Recombination completed
    • Gap filled in
  • DNA interstrand crosslink repair
    • interstrand crosslink
    • DNA Pol I
      • Removes crosslink region of one strand
    • Recombination
      • Strand exchange with same DNA
    • Nucleotide Excision Repair
  • Repair of alkylational bases
    • alkylational bases
    • glycosylase
      • Base excision repair
    • Methyltransferase
    • Adaptive response
      • ada、aidB、alkA、alkB
  • oxidative damage
    • mut genes
      • mutator type
• Error-prone DNA repair
  • A large amount of lesions
  • RecA was actived
  • LexA cleave itself
  • umuDC operon switch on
  • UmuD cleave itself
  • UmuD' and umuC form a clamp
  • DNA synthesis across from lesion
  • mistakes will frequently be made