What's the matter(with sb.)?
What's the happen to you?
What's the trouble with sb.?
Do/Does you/he/she/them+疾病?
What sort of pain do you get there?您什么地方痛?
How're you feeling now?您现在感觉怎么样了?
How long has it been this way?这样多久 了?
Do you feel better?你感觉好点了吗?
Are you feeling better? 你感觉好点了吗?
How are you today? 你今天感觉怎么样?