文献阅读领读--Nature期刊--综述--免疫专栏--第2017.10期

文献阅读领读--Nature期刊--综述--免疫专栏第2017.10期--Neutrophils as protagonists and targets in chronic inflammation.

nri.2017.10 Neutrophils as protagonists and targets in chronic inflammation

• Neutrophil production
  • Granulocyte colony‑stimulating factor takes centre stage during granulopoiesis.
  • Extramedullary neutrophil sources.
  • Granulopoiesis under stress.
• Plasticity in neutrophil phenotype and function
  • Ageing impairs neutrophil function and clearance.
  • Metabolic dysregulation primes neutrophils.
• Neutrophil networking
  • Platelet–neutrophil interactions trigger inflammation.
  • Prepacked neutrophil cargo attracts monocytes.
  • Decision-shaping interplay of neutrophils and macrophages.
  • Lymphatic transit of neutrophils provides access to lymphocytes and DCs.
• Neutrophils in chronic inflammatory disease
  • Neutrophils in metabolic disease: still plenty to learn.
  • Neutrophil recruitment precedes neurodegeneration.
  • Neutrophils initiate atherosclerosis.
  • Neutrophils in wound healing: basic considerations.
  • Beneficial roles of neutrophils in atherosclerosis-­related complications.
  • Paradoxical role of neutrophils during intestinal inflammation.
• Therapeutic implications
  • Preventing NET-driven inflammation.
  • Blocking neutrophil recruitment.
  • Therapeutic induction of the resolution of inflammation.
  • Neutrophil microparticles: magic in a box.
• The road ahead
  • Technical limitations
  • the actual turnover rate of neutrophils at sites of inflammation is unknown
  • the origin of neutrophil heterogeneity
  • the circadian and epigenetic control of neutrophil function
  • the importance of the microbiome in the production, function and clearance of neutrophils
  • the contribution of neutrophils to preserving tissue homeostasis rather than simply triggering inflammation
• Abstract: (1) The effects of ageing and chronic inflammation on granulopoiesis, neutrophil phenotype and function. (2) Emerging principles of neutrophil communication with other cells in settings of chronic inflammation. (3) The roles of neutrophils in chronic inflammatory disorders, such as obesity and atherosclerosis. (4) Emerging strategies for therapeutically targeting neutrophils.