导图社区 WHO造血与淋巴组织肿瘤分类，5th（2022）
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WHO造血与淋巴组织肿瘤分类，5th（2022）
根据IARC最新公布的第五版WHO造血和淋巴组织肿瘤分类目录制作，参考文献（whobluebooks.iarc.who.int/structures/haematolymphoid）。
编辑于2023-05-17 19:59:29 江苏省- 肿瘤
- 白血病
- 淋巴瘤
- 血液瘤
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WHO造血与淋巴组织肿瘤 （2022 5th）
1. Myeloid proliferations and neoplasms (MNs, 骨髓增生和髓系肿瘤）
Myeloid precursor lesions
Clonal Haematopoiesis
Clonal haematopoiesis
Clonal cytopenias of undetermined significance
Myeloid neoplasms, chronic (CMNs, 慢性髓系肿瘤）
Myeloproliferative neoplasms (MPNs, 骨髓增殖性肿瘤)
Chronic myeloid leukemia (CML)
典型特征：Ph染色体，BCR-ABL+，t(9;22)
典型细胞模型：
Chronic neutrophilic leukemia (CNL)
Chronic eosinophilic leukemia, not otherwise specified (CEL, NOS)
Polycythaemia vera (PV)
Essential thrombocythaemia (ET)
Primary myelofibrosis (PMF)
PMF, prefibrotic/early stage
PMF, overt fibrotic stage
Juvenile myelomonocytic leukemia (JMML)
Myeloproliferative neoplasm, not otherwise specified (MPNs,NOS)
Mastocytosis
Cutaneous mastocytosis
Systemic mastocytosis
Mast cell sarcoma
Myelodysplastic neoplasms (缩写MDS ！, 骨髓增生异常肿瘤）
MDS with low blasts and isolated 5q deletion (MDS-del(5q))
MDS with low blasts and SF3B1 mutation (MDS-SF3B1)
MDS with low blasts, not otherwise specified (MDS-NOS)
Myelodysplastic neoplasm with increased blasts
Myelodysplastic neoplasm with fibrosis
Myelodysplastic neoplasm, not otherwise specified (MDS, NOS)
Myelodysplastic neoplasm with biallelic TP53 alteration (provisional)
Myelodysplastic neoplasm with other defined driver gene alterations
Myelodysplastic neoplasms / acute myeloid leukaemia (MDS/AML)
Myelodysplastic neoplasm / acute myeloid leukaemia with NPM1 mutation
Myelodysplastic neoplasm / acute myeloid leukaemia with MECOM rearrangement
Myelodysplastic neoplasm / acute myeloid leukaemia, NOS
Myelodysplastic neoplasms of childhood
Refractory cytopenia of childhood
Childhood myelodysplastic syndrome
Myelodysplastic neoplasms with proliferative evolution
Chronic myelomonocytic leukaemia (CMML)
Myelodysplastic neoplasm with proliferative evolution and neutrophilia
Myelodysplastic neoplasm with proliferative evolution, SF3B1 mutation and thrombocytosis
Myelodysplastic neoplasm with proliferative evolution, not otherwise specified
Myeloid neoplasms, acute (AMNs, 急性髓系肿瘤，取代原先“AML及相关肿瘤”的分类）
Acute myeloid leukaemia with defining genetic abnormalities
Acute promyelocytic leukaemia
AML with RUNX1-RUNX1T1 fusion
t(8;21)(q22;q22.1)
AML with CBFB-MYH11 fusion
inv(16)(p13.1q22) or t(16;16)(p13.1;q22);
AML with KMT2A rearrangement
eg. t(9;11)(p21.3;q23.3)，MLLT3-KMT2A
AML with DEK-NUP214 fusion
t(6;9)(p23;q34.1)
AML with RBM15-MKL1 fusion
t(1;22)(p13.3;q13.3);
AML with BCR-ABL1 fusion
AML with NUP98 rearrangement
AML with other defined driver gene alterations
AML with mutated NPM1
AML with biallelic mutations of CEBPA
AML with GATA2, MECOM
inv(3)(q21.3q26.2) or t(3;3)(q21.3;q26.2);
AML with myelodysplasia-related cytogenetics
Acute myeloid leukaemia, defined by differentiation
AML with minimal differentiation
AML without maturation
AML with maturation
Acute basophilic leukaemia
AML with myelomonocytic differentiation
AML with monocytic differentiation
AML with plasmacytoid dendritic cell differentiation (provisional)
Pure erythroid leukaemia
Acute megakaryoblastic leukaemia
Myeloid sarcoma and others
Myeloid sarcoma
Myeloid neoplasms, secondary
Myeloid neoplasms and proliferations associated with antecedent or predisposing conditions
Myeloid neoplasm post cytotoxic therapy
Myelodysplastic neoplasm associated with germline predisposition
Acute myeloid leukaemia following other haematolymphoid malignancy
Myeloid proliferations associated with Down syndrome
Myeloid neoplasm associated with malignant germ cell tumour
2. Myeloid/lymphoid neoplasms and other leukaemias of ambiguous lineage (髓系/淋巴系肿瘤和其他未明系列肿瘤)
Myeloid/lymphoid neoplasms with eosinophilia and defining gene rearrangement (髓系/淋巴系肿瘤伴嗜酸性粒细胞增多和明确的基因重排)
Myeloid/lymphoid neoplasm with PDGFRA rearrangement
Myeloid/lymphoid neoplasm with PDGFRB rearrangement
Myeloid/lymphoid neoplasm with FGFR1 rearrangement
Myeloid/lymphoid neoplasm with PCM1-JAK2 fusion
Acute leukaemias of ambiguous lineage (ALAL, 未明系列急性白血病)
Mixed-phenotype acute leukaemia with BCR-ABL1 fusion (MPAL, BCR-ABL1)
Mixed-phenotype acute leukaemia with KMT2A rearrangement (MPAL, KMT2A rearrangement)
Mixed-phenotype acute leukaemia, B/myeloid (MPAL, B/myeloid)
Mixed-phenotype acute leukaemia, T/myeloid (MPAL, T/myeloid)
Acute leukaemia of ambiguous lineage, not otherwise specified (ALAL, NOS)
3. Histiocytic/Dendritic cell neoplasms (HDCNs, 组织细胞及树突状细胞肿瘤)
Plasmacytoid dendritic cell neoplasms
Plasmacytoid dendritic cell neoplasms
Mature plasmacytoid dendritic cell proliferation
Blastic plasmacytoid dendritic cell neoplasm
Langerhans cell neoplasms
Langerhans cells neoplasms
Langerhans cell histiocytosis
Langerhans cell sarcoma
4. Histiocyte/macrophage neoplasms
Histiocytic neoplasms
Juvenile xanthogranuloma
Erdheim-Chester disease
Rosai-Dorfman Disease
ALK related histiocytosis
Histiocytic sarcoma
Interdigitating dendritic cell
Interdigitating dendritic cell neoplasms
Indeterminate dendritic cell tumour
Interdigitating dendritic cell sarcoma
5. B-cell lymphoproliferative disorders and neoplasms
Tumour like lesions with B-lymphocytic predominance
Castleman disease
IgG4 related disease
Reactive B-cell rich lymphoid proliferations that can mimic lymphoma
Precursor B-cell neoplasms
B acute lymphoblastic leukaemia, B-ALL
B-ALL with BCR-ABL1 fusion
B-ALL with KMT2A rearrangement
B-ALL with ETV6-RUNX1 fusion
B-ALL/B-LBL (B acute lymphoblastic leukemia/lymphoma), BCR-ABL1-like features
B-ALL/B-LBL with other defined driver gene alterations
B-ALL/B-LBL with hyperdiploidy
B-ALL/B-LBL with hypodiploidy
B-ALL with germline predisposition
B-ALL with DUX4 rearrangement (provisional)
B-ALL with MEF2D rearrangement (provisional)
B-ALL with ZNF384 rearrangement (provisional)
B-ALL/B-LBL, not otherwise specified
Mature B-cell neoplasms
Chronic lymphocytic leukaemia/small lymphocytic lymphoma
Monoclonal B-cell lymphocytosis
Chronic lymphocytic leukaemia/small lymphocytic lymphoma
Splenic B-cell neoplasms
Hairy cell leukaemia
Splenic B-cell neoplasm with hairy cell features (formerly HCLv)
Splenic diffuse red pulp small B-cell lymphoma
Splenic marginal zone lymphoma
Lymphoplasmacytic lymphoma
Lymphoplasmacytic lymphoma
Marginal zone lymphoma
Indolent clonal marginal zone B-cell expansions
Extranodal marginal zone lymphoma
Nodal marginal zone lymphoma
Follicular lymphoma
In situ follicular B cell neoplasm
Follicular lymphoma
Paediatric-type follicular lymphoma
Duodenal-type follicular lymphoma
Gonadal follicular lymphoma
Cutaneous follicle centre neoplasms
Primary cutaneous follicle centre lymphoma
Mantle cell lymphoma
In situ mantle cell neoplasm
Mantle cell lymphoma
Leukaemic non-nodal mantle cell lymphoma
Transformations from indolent B cell lymphomas
Transformations from indolent B cell lymphomas
Large B-cell lymphoma
Diffuse large B-cell lymphoma, not otherwise specified
T-cell/histiocyte-rich large B-cell lymphoma
High-grade B-cell lymphoma with MYC and BCL2 rearrangements
ALK-positive large B-cell lymphoma
Large B-cell lymphoma with IRF4 rearrangement
High grade B-cell lymphoma with 11q aberration
Lymphomatoid granulomatosis
EBV-positive diffuse large B-cell lymphoma
Diffuse large B-cell lymphoma associated with chronic inflammation
Fibrin-associated diffuse large B-cell lymphoma
HHV8-unrelated effusion large B-cell lymphoma
Plasmablastic lymphoma
Primary diffuse large B-cell lymphoma of immune-privileged sites
Primary cutaneous diffuse large B-cell lymphoma (formerly leg type)
Intravascular large B-cell lymphoma
Primary mediastinal large B-cell lymphoma
Mediastinal grey zone lymphoma
Burkitt lymphoma
Burkitt lymphoma
High-grade B-cell lymphoma not otherwise specified
High-grade B-cell lymphoma, not otherwise specified
HHV8-associated B-cell neoplasms and lymphoproliferative disorders
Primary effusion lymphoma
HHV8-positive diffuse large B-cell lymphoma, not otherwise specified
HHV8-positive germinotropic lymphoproliferative disorder
Immunodeficiency-associated lymphoproliferative disorders
Primary immunodeficiency associated lymphoproliferative disorders
Secondary immunodeficiency associated lymphoproliferative disorders
Hodgkin lymphoma
Classic Hodgkin lymphoma
Nodular lymphocyte predominant Hodgkin lymphoma
Lymphoplasmacytic and plasma cell neoplasms
Monoclonal gammopathies
IgM Monoclonal gammopathy of undetermined significance
Non-IgM monoclonal gammopathy of undetermined significance
Monoclonal gammopathy of renal significance
Monoclonal immunoglobulin deposition diseases
Immunoglobulin-related (AL) amyloidosis
Monoclonal immunoglobulin deposition diseases
Heavy chain diseases
Mu heavy chain disease
Gamma heavy chain disease
Alpha heavy chain disease
Plasma cell neoplasms
Plasmacytoma
Plasma cell myeloma
Plasma cell neoplasms with associated paraneoplastic syndrome
6. T-cell lymphoproliferative disorders and neoplasms
Tumour-like lesions with T lymphocytic predominance
Kikuchi disease
Indolent T-lymphoblastic proliferation
Autoimmune lymphoproliferative syndrome
Precursor T-cell neoplasms
T acute lymphoblastic leukaemia / lymphoma
T acute lymphoblastic leukemia / lymphoma, not otherwise specified
Early T precursor acute lymphoblastic leukaemia / lymphoma
Mature T-cell neoplasms
Mature T-cell leukemias
T-cell prolymphocytic leukaemia
T-cell large granular lymphocytic leukaemia
Adult T-cell leukaemia/lymphoma
Sezary syndrome
Primary cutaneous T-cell neoplasm
Primary cutaneous CD4+ small or medium T-cell lymphoproliferative disorder
Mycosis fungoides
Lymphomatoid papulosis
Primary cutaneous anaplastic large cell lymphoma
Subcutaneous panniculitis-like T-cell lymphoma
Primary cutaneous gamma/delta T-cell lymphoma
Primary cutaneous CD8-positive aggressive epidermotropic cytotoxic T-cell lymphoma (provisional)
Primary cutaneous acral CD8-positive T-cell lymphoma
Primary cutaneous T-cell lymphoma, NOS
Intestinal T-cell neoplasms and lymphoproliferative disorders
Indolent T-cell lymphoproliferative disorder of the gastrointestinal tract
Enteropathy-associated T-cell lymphoma
Monomorphic epitheliotropic intestinal T-cell lymphoma
Intestinal T-cell lymphoma, NOS
Hepatosplenic T-cell lymphoma
Hepatosplenic T-cell lymphoma
Anaplastic large cell lymphoma
Anaplastic large cell lymphoma, ALK positive
Anaplastic large cell lymphoma ALK negative (DUSP22/TP63/NOS)
Anaplastic large cell lymphoma, breast implant-associated
Peripheral T-cell lymphoma with TFH phenotype
Follicular T-cell lymphoma
Angioimmunoblastic T-cell lymphoma
Peripheral T-cell lymphoma with TFH phenotype
Peripheral T-cell lymphoma
Peripheral T-cell lymphoma, NOS
EBV-positive nodal T-cell lymphoma
EBV-positive lymphoproliferative diseases of childhood
Severe mosquito bite allergy
Hydroa vacciniforme-like lymphoproliferative disorder
Chronic active EBV infection of T- and NK-cell type, systemic form
Systemic EBV+ T-cell lymphoma of childhood
7. NK-cell neoplasms
Chronic lymphoproliferative disorder of NK cells
Indolent NK-cell lymphoproliferative disorder of the gastrointestinal tract (provisional)
Aggressive NK-cell leukaemia
Extranodal NK/T-cell lymphoma, nasal type
EBV-positive nodal NK-cell lymphoma
NK acute lymphoblastic leukemia (provisional)
8. Lymphoid tissue stroma-derived neoplasms
Mesenchymal dendritic cell neoplasms
Follicular dendritic cell neoplasms
Follicular dendritic cell sarcoma
Inflammatory EBV+ follicular dendritic cell sarcoma
Fibroblastic reticular cell tumour
Splenic stromal tumours
Littoral cell angioma
Littoral cell angioma
9. Genetic tumour syndromes
Fanconi anaemia
Bloom syndrome
Ataxia-telangiectasia syndrome
RASopathies