Synthetic lethality

这是一篇关于Synthetic lethality的思维导图，导图内容简洁、逻辑清晰、重点突出，尤其适用于需要考试的学生党/上班族哦，大家一起快乐的学起来吧

Synthetic lethality

• Genetic events-1
• Genetic events-2
• Werner Syndrome
• WRN inactivation
• DNA mismatch repair (dMMR)
• WRN silencing
• WRN silencing
  • increased p53 S15 phosphorylation
• shRNA targeting WRN (shWRN1)
  • WRN levels recovered by three weeks
• immunoblot (IB)
  • three sgRNAs targeting WRN
  • WRN exon-intron junction (sgWRN-EIJ)
    • helicase inactivation
• RecQ DNA helicase WRN
  • exonuclease activity
  • helicase activity
  • Werner syndrome protein (WRN)
• microsatellite stable (MSS)
• microsatellite instability (MSI)
  • colon (15%)
  • gastric (22%)
  • endometrial(20–30%)
  • ovarian (12%)
• co-occurrence
• cell death
• cancer